A Complete Formula for Estrogen Balance and Detoxification

• Supports liver health
• Promotes detoxification of toxins, carcinogens and excess estrogen
• Reduces the risk of abnormal cellular growth related to excess
  estrogen in breast and cervical tissues
• Helps balance levels of “bad” and “good” estrogens
• Promotes healthy and regular menstruation

ESTRO ADAPT contains hops which are traditionally used in herbal medicine to help relieve nervousness and choline which supports liver function.

60 Vegi Caps 

Serving Size: 2 Capsules

• LIFENOL^® Hops extract† (15-25:1) 120 mg
• Calcium D-Glucarate 150 mg
• DIM (3,3’-Diindolylmethane) 108 mg
• Choline (bitartrate) 27.6 mg

Key non-medicinal ingredient: Broccoli extract *(300 mg)

†LIFENOL^® is a registered trademark of Naturex, Inc.

*Produced under patent US2006/010032 licensed from Caudill Seed Inc.

Key Feature: Effective combination for healthy estrogen balance

Suggested Use: Take 2 capsules per day with breakfast, or as directed by a qualified health care practitioner.

Cautions: Consult a health care practitioner if you are attempting to conceive, taking hormone replacement therapy or birth control pills or other medications, if symptoms persist or worsen, for use beyond 3 weeks, if you have or are predisposed to cancer or a liver disorder, or develop liver-related symptoms (e.g. abdominal pain, jaundice), depression and/or related diseases. Consumption of Hops with alcohol, other medications and/or natural health products with sedative properties is not recommended. Some people may experience drowsiness. Exercise caution if operating heavy machinery, driving a motor vehicle or involved in activities requiring mental alertness. Discontinue use if you experience joint pain or hot flashes. Discontinue use and consult a health care practitioner if you experience irregular menstruation. May temporarily alter urine colour. Consult a health care practitioner if urine does not normalize upon discontinued use.

Pregnancy/Nursing: Do not take

Source: Natural hops extract; Pharmaceutical synthesis

Main Indications:

• Cellular growth & differentiation Women’s health
• Detoxification
• Liver health
• PMS

Complementary Products: I3C, GLA 240, CurcuVIVA

Good Estrogens, Bad Estrogens

Estrogen is the primary female sex hormone, and is required for over 400 functions in the body. However, there are “good” and “bad” kinds of estrogens. High levels of some estrogen metabolites have been associated with an increased risk of breast and other cancers. Xenoestrogens, or synthetic estrogens encountered in the environment, can also be dangerous.

Achieving Balance

Diindolylmethane, or DIM, is a compound from broccoli that has been shown to promote the production of good estrogens and reduce the production of bad estrogens. It has been shown to halt the growth of breast and cervical cancer cells, and shows potential for reversing cervical dysplasia. 8-prenylnaringenin, from hops, is a potent phytoestrogen that also has anti-cancer activities.

Promoting Detoxification

Certain natural compounds can help enhance the detoxification of toxins and carcinogens, including xenoestrogens, by the liver. D-glucarate supports healthy detoxification and can even assist in the elimination of excess estrogen from the body. Sulforaphane activates phase II detoxification enzymes, which are involved in the breakdown of cancer causing compounds. Both of these compounds have the potential to help reduce the incidence of breast cancer. Choline supports liver function, which is the primary site of these detoxification processes.

Good vs. Bad Estrogens

Estrogen has long been considered a risk factor for a variety of women’s cancers, especially breast cancer. Research has shown that estrogens can be classified as “good” or “bad”. For example, 16α-hydroxylated estrogen metabolites are associated with an increased risk of breast cancer, while 2-hydroxylated estrogen metabolites are not.

Fortunately, there are natural solutions available that can help tip the balance towards the “good” estrogens, and to help detoxify and eliminate “bad” estrogens and xenoestrogens. The ingredients in Estro Adapt work together to promote a healthy estrogen balance and to promote the detoxification of harmful substances, thereby helping to reduce the risk of women’s cancers.

D-Glucarate

D-glucarate is a naturally occurring compound that plays a very important role in the detoxification of toxins and carcinogens. One very important detoxification pathway in the body is the glucuronidation pathway. Through glucuronidation, toxic substances, environmental carcinogens and even excess levels of estrogen are neutralized, and then eliminated from the body. This important detoxification process can be disrupted by the enzyme beta­glucuronidase, which acts to reactivate the neutralized toxins. The primary action of D-glucarate is to inhibit the enzyme beta-glucuronidase, thereby promoting detoxification and also encouraging healthy estrogen metabolism.

Research has shown that D-glucarate can inhibit breast cancer development in mice by as much as 70% and can lower serum estrogen levels by 23%. Preliminary studies in humans show that D-Glucarate supplements are safe, and that they have the same effects on beta-glucuronidase in people that they do in animals.

3,3’-Diindolylmethane (DIM)

DIM is a naturally occurring phytonutrient found in cruciferous vegetables like broccoli. DIM has been shown to promote the formation of 2-hydroxylated estrogen metabolites instead of 16α-hydroxylated estrogen metabolites, thereby pushing the balance of estrogen in the body towards “good” estrogens and reducing the production of “bad” estrogens. DIM has been shown to stop breast and cervical cancer cell growth in vitro. It has also been shown to block the activation of genes that promote cancer cell growth while activating genes that help prevent cancer. In humans, preliminary open-label testing has shown that treatment with DIM successfully resolved moderate to severe cervical dysplasia, a condition which is strongly correlated with the development of cervical cancer.

Sulforaphane

Sulforaphane is another naturally occurring substance found in broccoli. Sulforaphane is a potent inducer of phase II liver detoxification enzymes. The phase II detoxification enzymes are responsible for eliminating harmful toxins and carcinogens from the body. Additionally, research has shown that sulforaphane acts directly to inhibit cancer cell growth and to initiate apoptosis, or death, of cancer cells through a variety of mechanisms. In regards to women’s health, sulforaphane has been shown to inhibit the proliferation of breast cancer cells, and to reduce their expression of the estrogen receptor.

Hops Extract – 8-prenylnaringenin

8-prenylnaringenin (8PN) is a component found in hops that is a potent phytoestrogen, or plant estrogen. It has been shown to be of equal or greater potency as soy-derived phytoestrogens like genistein. In vitro 8PN has been shown to inhibit breast cancer cell proliferation by interfering with certain pathways mediated by the estrogen receptor. 8PN has also been shown to prevent angiogenesis (the formation of new blood vessels to feed tumors) both in test tube and animal studies. 8PN has also been shown to reduce menopausal symptoms including hot flashes. Lifenol®’s hops extract is standardized to contain an effective level of 8PN, and has been studied in numerous clinical trials.

Choline

Choline helps to support liver function and therefore detoxification processes that are carried out in the liver. Since phase II detoxification takes place in the liver, choline is an excellent addition to Estro Adapt to support the detoxification of xenobiotics or excess hormones.

*Prices and product availability are subject to change without notice. All specials and promotions limited to stock on hand.

 *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.